Regulation of nucleotide-excision repair

Across TCGA cell cohorts, RNA activity of the Regulation of nucleotide-excision repair pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP2, DOK1, and PDLIM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESRP2 grouped by Regulation of nucleotide-excision repair-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ESRP2 →	+1.932	+0.393	.006	<.001	3	5
BLOOD_Leukemia	DOK1 →	-0.908	-0.307	.004	.001	3	5
BREAST	PDLIM7 →	-0.968	-0.315	.002	.001	3	4
CNS	GLIPR1 →	-2.023	-0.690	.004	.005	3	4
LUNG_NSCLC_LUAD	SOAT1 →	-0.899	-0.248	.003	.002	3	4
LUNG_NSCLC_LUAD	TH →	+0.702	+0.315	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESRP2 by Regulation of nucleotide-excision repair activity — LUNG_SCLC

Explore this box plot interactively →