Regulation of barbed-end actin filament capping

Across TCGA patient cohorts, RNA activity of the Regulation of barbed-end actin filament capping pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARMIL1, BRCA1, and TNNC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of barbed-end actin filament capping activity versus CARMIL1 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARMIL1 →	+0.787	+1.007	<.001	<.001	3	6
LSCC	BRCA1 →	-0.796	-0.921	<.001	<.001	3	4
LSCC	TNNC1 →	+0.930	+0.841	<.001	.002	3	4
LSCC	GAL →	-1.118	-0.644	<.001	.008	3	4
LUAD	COASY →	-0.277	-0.635	.003	.005	3	4
OV	RN7SL128P →	+0.438	+0.773	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000812 vs CARMIL1 — GBM

Explore this scatter interactively →