Negative regulation of anoikis

Across TCGA patient cohorts, RNA activity of the Negative regulation of anoikis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL23AP72, FUT2, and TINCR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of anoikis activity versus RPL23AP72 in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL23AP72 →	+0.252	+0.169	.002	.009	3	3
HNSC	FUT2 →	+0.999	+0.109	.001	<.001	3	3
HNSC	TINCR →	+0.721	+0.093	<.001	.001	3	3
OV	SNORD15B →	+0.794	+0.277	.002	<.001	3	3
COAD	MFSD9 →	-0.402	-0.121	.001	.006	3	2
COAD	CCDC25 →	-0.454	-0.119	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000811 vs RPL23AP72 — LSCC

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