Regulation of bicellular tight junction assembly

Across TCGA patient cohorts, RNA activity of the Regulation of bicellular tight junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIK3_S626, SPEG_S2109, and WDR47_S297, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bicellular tight junction assembly activity versus SIK3_S626 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIK3_S626 →	+0.659	+0.896	<.001	<.001	3	4
OV	SPEG_S2109 →	-1.315	-1.187	<.001	<.001	3	3
OV	WDR47_S297 →	-0.852	-0.899	<.001	<.001	3	3
OV	EIF3E_S399 →	-1.084	-1.137	<.001	<.001	3	3
UCEC	F11R_S284 →	+0.651	+0.719	.001	.001	3	3
OV	MORF4L2_S71 →	+0.921	+0.737	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000810 vs SIK3_S626 — OV

Explore this scatter interactively →