Regulation of bicellular tight junction assembly

Across TCGA cell cohorts, RNA activity of the Regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT8, UNC13D, and EZR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bicellular tight junction assembly activity versus KRT8 in SKIN (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRT8 →	+2.165	+0.995	.002	.007	3	7
PANCREAS	UNC13D →	+3.874	+0.636	<.001	<.001	3	6
LARGE_INTESTINE	EZR →	+1.625	+0.390	<.001	<.001	3	6
BLOOD_Myeloma	ARAP2 →	+1.222	+1.185	.003	.003	3	5
BLOOD_Leukemia	WDFY1 →	-0.796	-0.714	.003	.001	3	5
OVARY	CDC42BPG →	+1.968	+0.588	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000810 vs KRT8 — SKIN

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