Regulation of synaptic vesicle clustering

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle clustering pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH2, TLN1_S1164, and C1QTNF5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle clustering activity versus CDH2 in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDH2 →	+1.118	+0.083	.001	.001	3	8
UCEC	TLN1_S1164 →	+0.705	+0.110	.003	.002	3	6
CCRCC	C1QTNF5 →	+0.480	+0.092	.004	<.001	3	6
LSCC	CCN1 →	+0.581	+0.062	.001	.001	3	6
UCEC	CEP170 →	+0.343	+0.116	<.001	<.001	3	6
UCEC	CFH →	+0.426	+0.109	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000807 vs CDH2 — LUAD

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