Regulation of synaptic vesicle clustering

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of synaptic vesicle clustering pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Regulation of synaptic vesicle clustering pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and SKCM, show the opposite pattern, with higher activity associated with better survival.

STAD, LUSC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.213	0.558	<.001	102	view →
LUSC	OS	Quartile	All	0.304	0.572	<.001	86	view →
LGG	DFS	Median	All	0.486	0.309	<.001	43	view →
SKCM	OS	Tertile	II,III,IV	0.504	0.245	<.001	36	view →
ACC	OS	Quartile	All	0.259	0.905	.001	35	view →
MESO	OS	Median	All	0.441	0.658	.006	32	view →
LAML	DFS	Quartile	All	0.606	0.227	<.001	28	view →
KIRP	DFS	Tertile	All	0.954	0.845	.011	20	view →
PAAD	DFS	Tertile	All	0.417	0.231	.012	11	view →
UVM	OS	Median	All	0.765	1.000	.007	11	view →
READ	DFS	Median	III,IV	0.675	0.356	.002	6	view →
LIHC	DFS	Median	All	0.172	0.365	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:2000807–STAD (OS)

Open the STAD breakdown →