Regulation of synaptic vesicle clustering

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle clustering pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROGDI, PGK1, and EXO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle clustering activity versus ROGDI in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ROGDI →	+0.576	+0.659	<.001	<.001	3	4
UCEC	PGK1 →	-0.808	-0.575	<.001	.004	3	4
LSCC	EXO1 →	-0.555	-0.503	.002	.001	3	4
PDAC	FAM136A →	-0.290	-0.554	.001	.002	3	4
UCEC	ANXA1 →	-0.900	-0.768	.006	<.001	3	4
GBM	HMGB3P7 →	+1.196	+0.672	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000807 vs ROGDI — GBM

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