Regulation of synaptic vesicle clustering

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle clustering pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BST2, DSTYK, and CDKN1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BST2 grouped by Regulation of synaptic vesicle clustering-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BST2 →	+1.871	+0.816	.009	.002	3	5
BONE	DSTYK →	+0.785	+1.274	.001	.006	3	4
LUNG_NSCLC_LUAD	CDKN1C →	-1.046	-0.887	.003	.006	3	4
URINARY_TRACT	MUS81 →	+0.759	+1.472	.007	.008	3	4
BREAST	NXF1 →	+0.505	+1.052	.002	<.001	3	4
BREAST	TNFAIP8L2 →	+0.100	+0.945	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BST2 by Regulation of synaptic vesicle clustering activity — CNS

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