Regulation of autophagosome assembly

Across TCGA cell cohorts, RNA activity of the Regulation of autophagosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD6, SIAH2, and NOL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD6 grouped by Regulation of autophagosome assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MFSD6 →	+1.274	+0.458	.002	.002	3	4
BLOOD_Lymphoma	SIAH2 →	+2.004	+0.400	.004	.005	3	4
URINARY_TRACT	NOL3 →	+1.583	+1.200	.006	.009	3	4
SOFT_TISSUE	CFAP97 →	-0.908	-1.334	.004	.002	3	4
PANCREAS	SLC22A4 →	+0.764	+0.216	.006	<.001	3	4
SKIN	GUF1 →	-0.463	-0.789	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD6 by Regulation of autophagosome assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →