Positive regulation of double-strand break repair

Across TCGA patient cohorts, RNA activity of the Positive regulation of double-strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC23A, F13A1, and LINC00702, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair activity versus SEC23A in LSCC (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEC23A →	-0.836	-0.409	.002	.001	3	5
BRCA	F13A1 →	-1.501	-0.666	<.001	<.001	3	5
BRCA	LINC00702 →	-0.406	-0.629	<.001	<.001	3	5
CCRCC	LIMD1 →	+0.258	+0.899	.002	.001	3	4
PDAC	MYH8 →	-0.289	-0.673	.002	.009	3	4
LSCC	SNORD126 →	+1.795	+0.410	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000781 vs SEC23A — LSCC

Explore this scatter interactively →