Positive regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular senescence pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNC3, NCBP3, and EXOC8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNC3 grouped by Positive regulation of cellular senescence-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KCNC3 →	+0.136	+1.147	.005	<.001	3	5
SOFT_TISSUE	NCBP3 →	-0.229	-1.862	.008	.001	3	4
BLOOD_Lymphoma	EXOC8 →	+0.243	+1.515	.003	<.001	3	4
BLOOD_Leukemia	EXOSC4 →	+0.266	+1.613	.004	<.001	3	4
LUNG_NSCLC_LUSC	NRK →	+0.270	+1.803	.004	<.001	3	4
SKIN	POLN →	+0.140	+1.153	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNC3 by Positive regulation of cellular senescence activity — PANCREAS

Explore this box plot interactively →