Positive regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, B2M, and PSMB8, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular senescence activity versus HLA-B in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HLA-B →	+5.822	+2.027	<.001	<.001	3	12
LARGE_INTESTINE	B2M →	+2.163	+1.352	<.001	<.001	3	10
LIVER	PSMB8 →	+3.764	+1.659	<.001	<.001	3	10
BREAST	HLA-A →	+3.307	+1.427	<.001	<.001	3	10
LIVER	HLA-F →	+3.022	+1.601	.007	.002	3	10
LIVER	NLRC5 →	+2.745	+1.659	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000774 vs HLA-B — LIVER

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