Negative regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP45, CALHM2, and ZNF618, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP45 grouped by Negative regulation of cellular senescence-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARHGAP45 →	+1.017	+0.218	<.001	.002	3	4
BONE	CALHM2 →	+2.340	+0.332	.004	.001	3	4
BONE	ZNF618 →	+1.344	+0.305	<.001	<.001	3	4
BONE	ASCL5 →	+0.772	+0.398	.004	.001	3	4
BLOOD_Lymphoma	NRIP2 →	+0.872	+0.402	.001	<.001	3	4
BLOOD_Leukemia	GLI4 →	+0.688	+0.421	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP45 by Negative regulation of cellular senescence activity — BREAST

Explore this box plot interactively →