Negative regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKM, RAD51D, and L2HGDH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular senescence activity versus PFKM in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PFKM →	+1.881	+0.301	.001	.003	3	5
SKIN	RAD51D →	+0.622	+0.193	.006	.003	3	4
KIDNEY	L2HGDH →	+1.165	+0.218	<.001	.002	3	4
OESOPHAGUS	SLC1A1 →	+1.817	+0.205	<.001	.001	3	4
BLOOD_Leukemia	P2RY2 →	-2.604	-0.133	<.001	.007	3	4
KIDNEY	TTC39C →	+1.375	+0.172	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000773 vs PFKM — STOMACH

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