Regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAP1, HLA-B, and HLA-C, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular senescence activity versus TAP1 in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAP1 →	+1.488	+0.234	<.001	<.001	3	10
OESOPHAGUS	HLA-B →	+3.870	+0.405	.002	<.001	3	9
BLOOD_Leukemia	HLA-C →	+1.998	+0.215	<.001	<.001	3	8
OESOPHAGUS	B2M →	+1.521	+0.341	.001	.001	3	7
PANCREAS	HLA-F →	+2.867	+0.328	<.001	<.001	3	7
URINARY_TRACT	BTN2A2 →	+2.125	+0.401	.007	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000772 vs TAP1 — BLOOD_Lymphoma

Explore this scatter interactively →