Negative regulation of cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoplasmic translation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF17, HDAC6, and ENPP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF17 grouped by Negative regulation of cytoplasmic translation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARHGEF17 →	+2.045	+1.706	.003	<.001	3	5
OVARY	HDAC6 →	+0.974	+1.248	<.001	<.001	3	5
BONE	ENPP5 →	+0.719	+1.328	.005	.001	3	4
BONE	KIF13A →	+1.617	+1.386	.005	.009	3	4
LUNG_SCLC	ZNF516 →	+2.133	+1.152	.009	.007	3	4
BREAST	TOMM20L →	+0.151	+0.831	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF17 by Negative regulation of cytoplasmic translation activity — BLOOD_Myeloma

Explore this box plot interactively →