Negative regulation of cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoplasmic translation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2A, MRPL45P2, and MAD1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEF2A grouped by Negative regulation of cytoplasmic translation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MEF2A →	+0.234	+0.118	<.001	.002	3	5
CNS	MRPL45P2 →	+0.243	+0.084	<.001	.002	3	4
CNS	MAD1L1 →	-0.237	-0.081	<.001	<.001	3	4
CNS	BICRA →	+0.292	+0.075	.008	.003	3	4
SOFT_TISSUE	EIF4B →	+0.487	+0.165	.003	.001	3	4
LARGE_INTESTINE	PIK3CA →	-0.262	-0.079	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEF2A by Negative regulation of cytoplasmic translation activity — SKIN

Explore this box plot interactively →