Negative regulation of cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoplasmic translation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK2, USP41, and BARD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoplasmic translation activity versus EIF2AK2 in BLOOD_Lymphoma (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EIF2AK2 →	+2.121	+1.446	<.001	<.001	3	5
BLOOD_Lymphoma	USP41 →	+2.765	+1.030	.007	.002	3	4
BONE	BARD1 →	+1.143	+1.594	<.001	<.001	3	4
BLOOD_Leukemia	TBC1D32 →	+0.840	+0.858	.002	<.001	3	4
BLOOD_Lymphoma	TRIM56 →	+0.632	+0.826	.003	.006	3	4
BLOOD_Leukemia	DPYD →	+1.223	+0.567	.008	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000766 vs EIF2AK2 — BLOOD_Lymphoma

Explore this scatter interactively →