Regulation of peptidyl-lysine acetylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-lysine acetylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNPO2, PDLIM3, and PTH1R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-lysine acetylation activity versus SYNPO2 in GBM (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYNPO2 →	-0.724	-0.272	<.001	<.001	3	7
UCEC	PDLIM3 →	-1.334	-0.168	.003	.002	3	6
BRCA	PTH1R →	-0.559	-0.194	<.001	<.001	3	6
OV	LMOD1 →	-1.393	-0.238	<.001	<.001	3	6
OV	ZCCHC24 →	-1.287	-0.189	<.001	.003	3	6
GBM	PTPRH →	-0.722	-0.182	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000756 vs SYNPO2 — GBM

Explore this scatter interactively →