Negative regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLM, EFTUD2, and MYO19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell differentiation activity versus BLM in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BLM →	+0.822	+0.274	<.001	<.001	3	6
UCEC	EFTUD2 →	+0.440	+0.200	.004	.001	2	7
LSCC	MYO19 →	+0.556	+0.217	<.001	<.001	3	6
UCEC	CENPF →	+1.238	+0.220	<.001	<.001	3	6
UCEC	HROB →	+0.690	+0.190	.002	.001	3	6
UCEC	TOP2A →	+1.184	+0.225	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000737 vs BLM — UCEC

Explore this scatter interactively →