Regulation of stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, ZNF84, and ZNF891, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell differentiation activity versus ARHGDIB in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARHGDIB →	+3.582	+0.223	.004	.001	3	7
SOFT_TISSUE	ZNF84 →	+0.847	+0.221	<.001	<.001	3	7
BONE	ZNF891 →	+1.347	+0.343	.001	.003	3	7
BLOOD_Leukemia	ZNF92 →	+0.628	+0.168	.002	<.001	3	7
BLOOD_Lymphoma	SCAF4 →	+0.612	+0.144	.001	.001	3	7
LUNG_SCLC	TMEM127 →	-0.861	-0.200	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000736 vs ARHGDIB — BLOOD_Lymphoma

Explore this scatter interactively →