Positive regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM14, KPNA1, and CIT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiac muscle cell differentiation activity versus RBM14 in BLOOD_Leukemia (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RBM14 →	+0.602	+0.419	<.001	.003	3	2
BONE	KPNA1 →	+0.955	+1.774	<.001	<.001	3	2
BONE	CIT →	+0.870	+1.774	.001	<.001	3	2
BONE	MFSD9 →	+0.710	+1.652	.001	.005	2	3
BONE	FAM122C →	+1.004	+1.794	.009	<.001	3	2
BONE	BTD →	+1.505	+1.811	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000727 vs RBM14 — BLOOD_Leukemia

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