Regulation of cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM2AKAP2, TLN1, and ARHGEF17, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell differentiation activity versus PALM2AKAP2 in UCEC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALM2AKAP2 →	+0.384	+0.070	<.001	<.001	3	9
UCEC	TLN1 →	+0.531	+0.087	<.001	<.001	3	8
COAD	ARHGEF17 →	+0.328	+0.035	<.001	.001	3	8
COAD	FERMT2 →	+0.566	+0.057	<.001	<.001	3	8
UCEC	TIMP3 →	+0.739	+0.062	<.001	.002	3	7
UCEC	ZCCHC24 →	+0.663	+0.106	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000725 vs PALM2AKAP2 — UCEC

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