Regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTF3, OTOL1, and TSPO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NTF3 grouped by Regulation of cardiac muscle cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NTF3 →	+0.247	+0.123	<.001	<.001	3	5
LUNG_SCLC	OTOL1 →	+0.330	+0.150	.006	<.001	3	4
OESOPHAGUS	TSPO →	-0.167	-0.119	.004	.008	3	4
URINARY_TRACT	ARHGAP33 →	-0.362	-0.240	<.001	<.001	3	4
URINARY_TRACT	ATP2B1 →	-0.277	-0.183	.003	.002	3	4
PANCREAS	WDR88 →	+0.204	+0.083	.006	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NTF3 by Regulation of cardiac muscle cell differentiation activity — KIDNEY

Explore this box plot interactively →