Positive regulation of transcription regulatory region DNA binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription regulatory region DNA binding pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK2, GBP5, and SAMHD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription regulatory region DNA binding activity versus DOK2 in OV (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOK2 →	-0.613	-0.059	<.001	.002	3	6
HNSC	GBP5 →	-0.680	-0.067	.005	<.001	3	6
OV	SAMHD1 →	-0.467	-0.050	.003	.001	3	5
OV	SASH3 →	-0.435	-0.066	.001	<.001	3	5
OV	CTSS →	-0.519	-0.051	.002	.002	3	5
OV	EVL →	-0.453	-0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000679 vs DOK2 — OV

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