Positive regulation of transcription regulatory region DNA binding

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of transcription regulatory region DNA binding pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 22 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Positive regulation of transcription regulatory region DNA binding pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and READ, show the opposite pattern, with higher activity associated with better survival.

ACC, CHOL, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.640	0.152	.001	42	view →
CHOL	OS	Median	All	0.193	0.881	.003	30	view →
SKCM	DFS	Median	III,IV	0.174	0.325	.003	27	view →
READ	OS	Tertile	II,III,IV	0.882	0.519	.005	25	view →
BLCA	OS	Median	All	0.673	0.560	.010	24	view →
LUAD	DFS	Tertile	III,IV	0.587	0.160	.014	20	view →
KIRP	DFS	Tertile	IV	0.049	0.765	.010	18	view →
LIHC	DFS	Quartile	II,III,IV	0.249	0.558	.002	17	view →
UVM	DFS	Median	III,IV	0.302	0.815	.014	16	view →
KIRC	DFS	Tertile	II,III,IV	0.470	0.660	.019	12	view →
LGG	OS	Median	All	0.609	0.459	.008	10	view →
MESO	DFS	Tertile	IV	0.679	0.231	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:2000679–ACC (DFS)

Open the ACC breakdown →