Positive regulation of transcription regulatory region DNA binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RB1, MESP1, and MAP4K1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription regulatory region DNA binding activity versus RB1 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RB1 →	+0.660	+0.233	.008	.006	3	5
HNSC	MESP1 →	-0.773	-0.178	.002	.001	3	5
HNSC	MAP4K1 →	-0.729	-0.156	.003	.005	3	4
HNSC	IL20RB-AS1 →	+1.142	+0.147	.001	.003	3	4
HNSC	PI3 →	+2.232	+0.182	.001	.001	3	4
BRCA	GJB2 →	+1.227	+0.151	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000679 vs RB1 — BRCA

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