Positive regulation of transcription regulatory region DNA binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISYNA1, TXLNA, and EVI2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ISYNA1 grouped by Positive regulation of transcription regulatory region DNA binding-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ISYNA1 →	+1.975	+1.039	.001	.004	3	4
PANCREAS	TXLNA →	+0.946	+1.247	<.001	<.001	3	4
URINARY_TRACT	EVI2B →	-0.533	-2.068	.006	.001	3	4
BONE	LRRC37A3 →	+1.142	+1.304	.006	.002	3	4
BONE	NBPF12 →	+0.720	+1.046	.005	.005	3	4
LUNG_NSCLC_LUAD	SNRNP25 →	+0.823	+0.768	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ISYNA1 by Positive regulation of transcription regulatory region DNA binding activity — PANCREAS

Explore this box plot interactively →