Positive regulation of transcription regulatory region DNA binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1GALT1, H1-0, and C3orf18, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription regulatory region DNA binding activity versus C1GALT1 in LUNG_NSCLC_LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1GALT1 →	+0.656	+0.125	.002	.005	2	8
BLOOD_Leukemia	H1-0 →	+3.559	+0.781	<.001	.003	2	7
URINARY_TRACT	C3orf18 →	+2.472	+0.439	<.001	<.001	3	5
BONE	PPP2R5E →	+1.291	+0.299	<.001	<.001	3	5
LARGE_INTESTINE	ANKIB1 →	+0.501	+0.194	.006	.003	3	5
LUNG_NSCLC_LUAD	ATP5F1C →	-0.608	-0.137	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000679 vs C1GALT1 — LUNG_NSCLC_LUAD

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