Negative regulation of type B pancreatic cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of type B pancreatic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB9A, PLEKHA4, and PHYH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB9A grouped by Negative regulation of type B pancreatic cell apoptotic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RAB9A →	-0.508	-0.803	.001	.002	3	4
BLOOD_Myeloma	PLEKHA4 →	-2.091	-1.769	<.001	<.001	3	4
CNS	PHYH →	-0.652	-0.769	.003	.003	2	4
CNS	IL7R →	-2.402	-1.166	.006	<.001	3	3
CNS	GSTM4 →	-1.251	-1.031	.008	.001	3	3
CNS	MAPK15 →	+0.578	+0.846	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB9A by Negative regulation of type B pancreatic cell apoptotic process activity — CNS

Explore this box plot interactively →