Negative regulation of motor neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of motor neuron apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLE3, PXN, and CBFA2T2_S33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of motor neuron apoptotic process activity versus TLE3 in BRCA (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLE3 →	+0.304	+0.046	.006	.003	3	5
GBM	PXN →	-0.251	-0.059	.002	.001	3	5
LSCC	CBFA2T2_S33 →	+0.334	+0.051	.008	<.001	3	4
LSCC	CELF2 →	+0.404	+0.062	<.001	<.001	3	4
UCEC	CEP170_S359 →	+0.346	+0.077	.002	.001	3	4
BRCA	REPS2 →	+0.571	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000672 vs TLE3 — BRCA

Explore this scatter interactively →