Negative regulation of motor neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of motor neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV8-5, FUOM, and VTI1BP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of motor neuron apoptotic process activity versus TRAV8-5 in HNSC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAV8-5 →	+0.326	+0.286	<.001	.004	3	3
GBM	FUOM →	+0.537	+0.822	.001	.001	3	3
GBM	VTI1BP4 →	-0.462	-0.827	.001	.004	3	3
GBM	BCAS1 →	+1.838	+0.862	.002	.004	3	3
GBM	RNF13 →	+0.488	+0.928	<.001	.001	3	3
BRCA	HCAR1 →	+1.110	+0.685	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000672 vs TRAV8-5 — HNSC

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