Regulation of motor neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of motor neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERCC6L, ARRB1, and SEPTIN11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of motor neuron apoptotic process activity versus ERCC6L in PDAC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ERCC6L →	-0.242	-0.359	.008	.004	3	4
GBM	ARRB1 →	+0.592	+0.835	<.001	<.001	3	4
LUAD	SEPTIN11 →	-0.299	-0.240	.001	.001	3	3
LUAD	RPL12P20 →	+0.758	+0.223	<.001	.003	3	3
BRCA	AMMECR1 →	-0.679	-0.868	<.001	<.001	3	3
GBM	ELMO1 →	+0.596	+0.728	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000671 vs ERCC6L — PDAC

Explore this scatter interactively →