Regulation of motor neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of motor neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRLF1, VPS54, and TMEM59L, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of motor neuron apoptotic process activity versus CRLF1 in URINARY_TRACT (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CRLF1 →	+2.227	+0.189	.001	<.001	3	14
LIVER	VPS54 →	+1.395	+0.336	<.001	<.001	3	10
PANCREAS	TMEM59L →	+1.443	+0.149	.001	<.001	3	8
LARGE_INTESTINE	CD82 →	-1.554	-0.104	.001	<.001	3	7
LIVER	MPHOSPH10 →	+0.950	+0.296	.003	.002	3	7
LIVER	MVP →	-1.784	-0.213	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000671 vs CRLF1 — URINARY_TRACT

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