Negative regulation of stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WRNIP1_S153, UCHL1, and SH3GLB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell proliferation activity versus WRNIP1_S153 in GBM (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WRNIP1_S153 →	+0.773	+0.310	.002	<.001	3	3
LSCC	UCHL1 →	+0.909	+0.662	.002	<.001	3	3
GBM	SH3GLB1 →	-0.286	-0.234	<.001	<.001	3	2
BRCA	SHROOM1_T81 →	-0.651	-0.784	<.001	<.001	3	2
OV	BAZ2A_S1051 →	+1.353	+0.897	<.001	.002	3	2
BRCA	TP53_S315 →	+1.368	+0.790	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000647 vs WRNIP1_S153 — GBM

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