Negative regulation of stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSGIN2, ARHGEF37, and NRSN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSGIN2 grouped by Negative regulation of stem cell proliferation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OSGIN2 →	-0.947	-1.177	.005	.005	3	4
BREAST	ARHGEF37 →	-1.326	-0.766	.003	.002	3	3
STOMACH	NRSN2 →	-3.526	-1.487	<.001	.005	3	3
STOMACH	DLX1 →	-3.210	-1.466	.005	.004	3	3
STOMACH	KLHDC8B →	-2.140	-0.943	<.001	.002	3	3
STOMACH	LAMA3 →	+2.692	+1.125	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSGIN2 by Negative regulation of stem cell proliferation activity — LUNG_SCLC

Explore this box plot interactively →