Negative regulation of stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC7, DCBLD2, and FAM83F, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell proliferation activity versus ZCCHC7 in BREAST (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZCCHC7 →	+0.671	+0.471	.002	.002	3	4
OESOPHAGUS	DCBLD2 →	-3.364	-0.462	.002	<.001	3	3
STOMACH	FAM83F →	+2.106	+0.696	.007	.004	3	3
OESOPHAGUS	MKKS →	+1.331	+0.462	.003	<.001	3	3
BREAST	DDC →	+1.284	+0.413	.004	.009	3	2
OESOPHAGUS	ADAM20 →	-0.321	-0.462	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000647 vs ZCCHC7 — BREAST

Explore this scatter interactively →