Negative regulation of stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT1, COG2, and QDPR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell proliferation activity versus FERMT1 in BREAST (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FERMT1 →	+1.840	+0.602	.001	.001	3	5
LARGE_INTESTINE	COG2 →	+1.008	+1.212	<.001	.002	3	3
LARGE_INTESTINE	QDPR →	+0.595	+0.749	.001	.009	3	3
LARGE_INTESTINE	SUGT1 →	+1.038	+0.949	<.001	<.001	3	3
LUNG_NSCLC_LUAD	HSPA14 →	+0.569	+0.345	.004	.008	2	3
BREAST	ARHGEF16 →	+0.996	+0.379	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000647 vs FERMT1 — BREAST

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