Positive regulation of early endosome to late endosome transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of early endosome to late endosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPM1F, TUBB6, and EFEMP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of early endosome to late endosome transport activity versus PPM1F in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPM1F →	+0.195	+0.031	<.001	<.001	3	8
BRCA	TUBB6 →	+0.365	+0.030	<.001	<.001	3	7
BRCA	EFEMP1 →	+0.481	+0.030	.003	<.001	3	7
OV	NID2 →	+0.500	+0.067	<.001	<.001	3	7
BRCA	PDLIM3 →	+0.465	+0.041	.003	<.001	3	7
GBM	SERPINA4 →	+0.443	+0.055	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000643 vs PPM1F — BRCA

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