Regulation of primary miRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of primary miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC26_S42, IGHMBP2_S716, and DAXX_S668, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of primary miRNA processing activity versus CDC26_S42 in OV (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDC26_S42 →	-1.705	-0.659	<.001	<.001	3	3
OV	IGHMBP2_S716 →	-1.502	-0.553	.001	.003	2	4
UCEC	DAXX_S668 →	+0.859	+0.799	<.001	.001	3	3
OV	DYNC1I2_S104 →	-1.208	-0.967	<.001	<.001	3	3
UCEC	MECP2_T400 →	+0.833	+0.755	<.001	<.001	3	3
OV	CBY1 →	+2.513	+1.759	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000634 vs CDC26_S42 — OV

Explore this scatter interactively →