Regulation of primary miRNA processing

Across TCGA cell cohorts, RNA activity of the Regulation of primary miRNA processing pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are JW-7-24-1, Dacinostat, and QL-X-138, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JW-7-24-1 grouped by Regulation of primary miRNA processing-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	JW-7-24-1 →	-1.001	-0.945	<.001	.049	3	3
BLOOD_Leukemia	Dacinostat →	-0.411	-1.131	.004	.018	3	2
BLOOD_Leukemia	QL-X-138 →	-0.553	-1.292	.009	.005	3	2
BONE	741909 →	+1.323	+0.340	.043	.036	2	3
BLOOD_Leukemia	Gefitinib →	-0.261	-1.136	<.001	.004	3	1
BLOOD_Leukemia	Lestaurtinib →	-0.509	-0.908	.021	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JW-7-24-1 by Regulation of primary miRNA processing activity — BLOOD_Lymphoma

Explore this box plot interactively →