Regulation of pre-miRNA processing

Across TCGA patient cohorts, RNA activity of the Regulation of pre-miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBBP7, SYS1, and TGOLN2_S71, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pre-miRNA processing activity versus RBBP7 in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBBP7 →	+0.262	+0.072	.006	.003	3	5
PDAC	SYS1 →	-0.340	-0.050	.003	<.001	3	4
HNSC	TGOLN2_S71 →	-0.340	-0.082	<.001	.001	3	4
HNSC	PPIP5K2 →	-0.094	-0.063	.009	<.001	3	4
BRCA	SIGLEC10 →	-0.661	-0.058	<.001	.001	3	4
BRCA	SORD →	+0.398	+0.042	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000631 vs RBBP7 — UCEC

Explore this scatter interactively →