Positive regulation of miRNA metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NASP, TROAP, and SNHG12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of miRNA metabolic process activity versus NASP in PDAC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NASP →	+0.249	+0.188	<.001	<.001	3	4
PDAC	TROAP →	+0.361	+0.169	.005	.007	3	4
LSCC	SNHG12 →	+0.428	+0.819	.002	.001	3	4
LSCC	SNHG1 →	+0.335	+0.447	.004	.006	3	4
OV	HSPA8P15 →	+0.489	+0.518	.009	.005	3	4
LUAD	PHKG1 →	+0.360	+0.485	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000630 vs NASP — PDAC

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