"Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA patient cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC6, WDR90, and TMEM97, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus CDC6 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC6 →	+1.055	+0.231	<.001	<.001	3	5
UCEC	WDR90 →	+0.633	+0.230	.006	<.001	3	5
HNSC	TMEM97 →	+1.043	+0.160	.002	<.001	3	4
HNSC	NSD2 →	+0.603	+0.159	.003	.002	3	4
HNSC	CEP72 →	+1.083	+0.185	<.001	<.001	3	4
HNSC	RFC3 →	+0.743	+0.148	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000622 vs CDC6 — UCEC

Explore this scatter interactively →