"Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDYL2, IGFBP2, and HEY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDYL2 grouped by "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CDYL2 →	-1.066	-0.106	.006	.006	3	4
LIVER	IGFBP2 →	-3.273	-0.223	.001	.001	3	4
LUNG_SCLC	HEY1 →	-2.904	-0.151	.001	.002	3	4
BLOOD_Leukemia	AGMAT →	-1.340	-0.176	.002	.002	3	3
CNS	NEK6 →	-0.737	-0.150	.004	<.001	3	3
OVARY	BID →	-0.978	-0.158	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDYL2 by "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity — PANCREAS

Explore this box plot interactively →