"Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"

Across TCGA cell cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TATDN2, DNMT1, and UPF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" activity versus TATDN2 in KIDNEY (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TATDN2 →	+0.989	+0.091	.004	.005	3	7
PANCREAS	DNMT1 →	+1.475	+0.268	.001	<.001	3	6
BREAST	UPF1 →	+0.640	+0.159	.001	.001	3	6
LARGE_INTESTINE	WRAP53 →	+0.649	+0.138	<.001	<.001	3	6
LIVER	PLXNA1 →	+1.454	+0.193	.002	.007	3	5
LIVER	SH3GL1 →	+1.092	+0.182	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000622 vs TATDN2 — KIDNEY

Explore this scatter interactively →