Positive regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Positive regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDLIM1, RPS6, and SEC16A_S1305, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Arp2/3 complex-mediated actin nucleation activity versus PDLIM1 in GBM (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDLIM1 →	-0.708	-0.104	<.001	<.001	3	5
GBM	RPS6 →	-0.417	-0.085	<.001	<.001	3	5
GBM	SEC16A_S1305 →	-0.590	-0.098	<.001	<.001	3	5
HNSC	UCHL1 →	+1.088	+0.084	<.001	.003	3	5
GBM	PARP4 →	-0.441	-0.110	<.001	<.001	3	5
BRCA	AP3M1 →	-0.173	-0.034	.008	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000601 vs PDLIM1 — GBM

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