Positive regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA patient cohorts, RNA activity of the Positive regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARCL1, JAM2, and CCDC47, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Arp2/3 complex-mediated actin nucleation activity versus SPARCL1 in CCRCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPARCL1 →	+1.025	+0.394	.003	.007	3	4
GBM	JAM2 →	+0.868	+0.165	<.001	<.001	3	4
COAD	CCDC47 →	+0.263	+0.092	.006	.005	3	3
BRCA	GULP1 →	+0.719	+0.083	.004	.005	3	3
HNSC	LIPH →	+0.910	+0.126	.002	.005	3	3
GBM	RORB-AS1 →	+0.901	+0.119	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000601 vs SPARCL1 — CCRCC

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