Positive regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Positive regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAMD2B, EPCAM, and HERC6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRAMD2B grouped by Positive regulation of Arp2/3 complex-mediated actin nucleation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GRAMD2B →	+1.020	+0.561	.002	.009	3	4
LUNG_NSCLC_LUAD	EPCAM →	+2.977	+0.850	<.001	.002	3	4
SKIN	HERC6 →	+0.619	+1.278	.002	<.001	3	3
LUNG_NSCLC_LUSC	TTC12 →	+0.970	+1.312	.001	.007	3	3
BLOOD_Lymphoma	THAP2 →	-1.069	-2.116	.004	.001	2	4
BLOOD_Myeloma	PPOX →	-0.753	-1.624	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRAMD2B by Positive regulation of Arp2/3 complex-mediated actin nucleation activity — BREAST

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